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List of omeprazole side effects and when to call 111

Omeprazole is a commonly prescribed medication that treats a number of conditions

Those who have been prescribed omeprazole are being warned of the potential risk of serious side effects that may necessitate a 111 call or an urgent GP appointment. Omeprazole, a proton pump inhibitor (PPI), is commonly prescribed in the UK to treat conditions such as heartburn, stomach ulcers, and gastro-oesophageal reflux disease (GERD).

The medication works by reducing the amount of acid in your stomach and can be taken in various forms including capsules, tablets, or liquid. Generally, it is advised not to take omeprazole for more than two weeks if purchased without a prescription, as it can cause a variety of side effects.

However, your doctor may advise you to take it for longer on prescription, depending on the severity of your symptoms.

Side effects of omeprazole

Like many medications, omeprazole can cause side effects, although these vary from person to person. NHS guidance highlights certain side effects that are more likely if you take omeprazole consistently for a year or more.

However, there are some side effects outlined in NHS guidance, which it highlights are more likely to take place if you take omeprazole for a year or more consistently. Common, more mild, side effects of taking omeprazole can include:

  • Flatulence
  • Nausea
  • Vomiting
  • Stomach pain
  • Headache
  • Constipation
  • Diarrhoea

More serious side effects include:

  • A form of lupus that can cause joint pain and rashes
  • Weakened bones, increasing the risk of breaks
  • Low vitamin B12 levels (can cause tiredness, muscle twitches, and dizziness)
  • Anaphylaxis – a serious allergic reaction that can cause a swollen tongue or throat, a raised itch rash, and difficult breathing
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The guidance also emphasises that you should ring 111 if “you’re taking omeprazole and think you might be having serious side effects”. It’s crucial to remember that the above is not an exhaustive list of the potential side effects you could experience while taking omeprazole and you should always read the leaflet that comes with the medication for more information.

Full details and guidance on taking omeprazole, and its potential side effects, can be found on the NHS website here.


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